Enabling Technology for your Success
Boehringer Ingelheim's Pharma Chemicals business uses state-of-the-art technologies and methods to support process development. We can help you shorten process development timelines: Methods such as Design of Experiments (DoE), Parallel Synthesis, Process Analytical Technology (PAT) and Quality-by-Design (QbD) create the basis for in-depth process knowledge and robust manufacturing processes yielding high quality APIs and Formulations.
Physical properties of Active Pharmaceutical Ingredients (APIs)
Physical properties of the API are always at the center of our attention.
Crystal engineering, understanding substances’ polymorphism and methods to control particle size distribution are essentials for reproducing API quality. Pharma Chemicals has the required equipment and the professional skills to fulfill all aspects of API development in time and to full customers' satisfaction.
Our core areas of Chemical expertise
- Asymmetric hydride reduction
- Asymmetric organolithium chemistry
- Chiral pool syntheses
- Cyanobromination
- Enantiomeric resolution
- Extraction of natural products
- Glycosidation
- Grignard reactions
- Hazardous reaction e.g. bromination
- Hydrogenation
- Modern organometallic chemistry including low temperature (-100°C)
- Nucleoside coupling
- Particle size engineering- milling and micronization
- Pd-catalyzed cross-coupling reactions
- Phase transfer catalyzed reactions
- Purification by liquid-liquid extraction
- Transition metal-catalyzed cross-coupling reactions
- Robinson-Schöpf reactions
Additional enabling techniques applied for APIs
- Counter current liquid-liquid partitioning
- Large scale solvent degassing
- Thin-layer wiped film distillation
Key services for Formulations
- Potent compound capabilities (OEL > 0.1 microgram/m³)
- Milling and Micronization
- Encapsulation technology
- Pediatric Formulations
- Nasal suspensions and solutions
- Bilayer tablets
- Micro dosing for highly active APIs (below 1 mg per tablet / capsule)
- Tablet printing
- Wet and dry granulation
- Tailored supply solutions for emerging markets in Eastern Europe, South America and Asia.
