BI-HEX®: Fast track - high Expression
The Boehringer Ingelheim High Expression Technology (BI HEX®) is an established high expression platform technology which enables fast-track development of high-quality, high-titer processes for production of biopharmaceuticals from mammalian cell cultures (CHO cells).
State-of-the-art technology platform
Our BI-HEX® platform meets the demands for shorter development times to first use of a new biologic entity in humans. Early focus on commercial scale potential avoids unnecessary costs and delays later.
The system has proven that more than six grams of protein per litre can be produced within eleven days, which is about four times above the current industrial standard for products on the market.
BI-HEX® provides
- Efficient vector systems with novel genetic elements for high-level of product expression and enrichment of high producers
- Serum-free transfection, selection and cultivation of suspension-adapted CHO-DG44 cells
- Cultivation in chemically defined media eliminating long adaptation processes
- Sophisticated design of high throughput screening platforms, including platform media and well-characterized down-scale models deliver highly productive, robust clones growing to high densities
- Fed batch process platform with well characterised chemically defined media and feeds
- cGMP cell banking of master and working cell banks in chemically defined media
For our contract manufacturing customers, the BI-HEX system is royalty-free.
