Value through Innovation10 February 2016

Developing compelling brands for consumers

We aim to create and drive inspiring and sustainable solutions that will efficiently develop compelling and true global brands for consumers.

Core brands

ANTISTAX®

Antistax® - the leading consumer brand for leg health

How Antistax® works:

For many years, researchers puzzled over the fact that French wine growers almost never suffered from vein disorders. Then they discovered that the farmers were making infusions and poultices from vine leaves to treat their heavy, swollen and painful legs. This home remedy was proving to be a great success.

Pharmacologists analyzed the active ingredients of the red vine leaf and developed it into an effective extract, containing a standardized mix of natural flavonoids. This pure herbal extract is the basis of the Antistax® product range for tired, heavy legs which have been proven to improve blood circulation and reduce swelling.

Antistax®
360mg tablets have a clinically proven effect on the reduction of edema caused by chronic venous insufficiency, as well as relieving pain and feelings of tiredness and heaviness in the legs. Antistax® therefore delivers a significant improvement to the quality of life of the relevant population.

In most markets the Antistax® 360mg tablets are marketed as a medicinal product.

Antistax® also markets cosmetic products for sufferers from mild leg issues, e.g. the Fresh Leg Gel (125 ml) which provides an instant cooling effect.

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.

BISOLVON®

Unique and comforting solutions for chesty coughs

Coughing can be a distressful and uncomfortable experience. It is, however, an integral part of the body's self-cleaning mechanism and part of the body's self-protective response. A cough mainly has the function of clearing the airways, thereby protecting the lungs.

From a medical perspective, cough is the most common symptom of clinical importance and the most frequent reason to consult a doctor.  The clinical symptoms of cough and expectoration (coughing up mucus) have led to the development of drugs that affect respiratory mucus: the so-called mucoactive agents.

Basically, there are two kinds of cough during a common cold infection: chesty (productive) and dry (non-productive, persistent, and irritating).

A chesty cough, also known as a productive cough, is normally the result of a viral upper respiratory tract infection, such as the common cold. The infection causes the mucous membrane of the airways to become inflamed and to produce thick, sticky mucus, so that it is no longer removed by the body’s normal cleaning action and clogs up the airways. Coughing helps push out this sticky phlegm. Inflammation and too much thick mucus narrow the airways, make breathing difficult, and can promote bacterial infection.

A non-productive cough is dry and tickling - a repeated irritation of the respiratory tract, usually without producing phlegm. Besides respiratory tract infections, this cough can for example also be caused by cigarette smoke, dust or allergies. Sometimes it remains for a couple of days or even weeks as a post symptom of a common cold.

Bromhexine, the active agent in Bisolvon® is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion making it more easily to be expectorated. Bromhexine enhances also mucus transport by reducing mucus viscosity and by activating the ciliated epithelium. In clinical studies, Bisolvon® showed secretolytic and secretomotoric effects in the bronchial tract area which facilitates expectoration and eases cough.

Bisolvon® has been on the market since 1963. Bromhexine is contained in various formulations of Bisolvon®. There are high and low strength syrups 8mg/5ml, 4 mg/ml, tablets and fast dissolving tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/ 5 ml), adapted to the need of the patients. The posology varies with the age, but there are products for all age groups from infant on.

Beyond the cough indications, Bisolvon® offers a variety of cough and cold products in different formats.

Bisolvon® trusted to care for cough and colds.

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.

BUSCOPAN®

Abdominal cramping, pain and discomfort are a common ailment. Approximately 1 of 4 persons worldwide suffers on a regular basis.

For millions of people around the world, Buscopan® is the first choice for reliable relief from the pain and discomfort due to abdominal cramps. Its unique proven formula gently relaxes the cramped muscles of the digestive tract and acts only where the pain occurs and therefore relieves the spasms that cause abdominal pain. The active ingredient in Buscopan® is hyoscine butylbromide which is basically a natural substance extracted from Duboisia plant.

Buscopan® offers a full line of products – the mono variant but also different combinations with analgesics (paracetamol, ibuprofen and metamizol/dipyrone) as well as different formats (tablets, drops, suppositories, syrup, solutions for intravenous injection).

Buscopan® - our consumer brand for the treatment of abdominal pain and cramps.

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.




DULCOLAX®

Dulco® - Dependable Constipation Relief

Our constipation expert brand Dulco® is the number 1 global laxative brand and is marketed in more than 100 countries.

Dulco® offers a range of dependable solutions to relieve you from constipation.

Predictable relief with Dulcolax®: in minutes with suppositories, overnight with tablets, pearls or liquid. Dulcolax® contains the active ingredient bisacodyl. The tablets have a unique comfort coating which prevents them from being dissolved until they reach the colon where the active ingredient is released, ensuring it works right where it's needed.

DulcoEase® and DulcoSoft® relieve with a gentle mode of action to make it more comfortable to go. DulcoEase® is available in soft capsules, DulcoSoft® in flavorless oral solution and powder.

And because constipation and flatulence often happen together, DulcoGas® is our solution to have a quick relief of bloating – wherever you need it; thanks to its individual stick sachets to take on-the-go.

For more information on the best way to treat the different constipation symptoms visit our websites.

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.

EVE®

EVE® - pain relief for the independent Japanese woman

The EVE® product range was the first launched ibuprofen therapy in Japan. It is uniquely positioned for the treatment of headaches as well as menstrual pain.

All EVE® products contain the active pharmaceutical ingredients ibuprofen, allylisopropylacetylurea, and caffeine.

EVE® A effectively targets menstrual and general pain precisely at the source.

EVE® A EX with higher ibuprofen dosage; brings precise and effective relief from stronger headaches and menstrual pain.

EVE®  QUICK provides a specialized solution for headaches, providing fast-acting and highly effective relief while being gentle on the stomach.

With magnesium oxide to provide clinically proven faster relief from headache than any other ibuprofen analgesic.

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.

MUCOANGIN®

When you have a sore throat do you feel excluded from your daily life? Does having a sore throat compromise your ability to carry on with your day?

The throat is quite a small area but it’s very important – and very sensitive. That’s why even a mild sore throat can be such an uncomfortable interruption to enjoying your daily life.

Pain in sore throat is the hallmark of acute pharyngitis, which is usually caused by a viral infection. The infection is self-limited and recovery is normally within a couple of days. What is most troubling is the continuous pain in the throat, which is worst when swallowing. The pain impacts many activities of daily life and the main goal of the treatment is thus to reduce pain.

Mucoangin® contains ambroxol, an efficacious and well-tolerated local anesthetic which relieves sore throat pain by blocking the pain receptors in the throat.

State-of-the-art clinical studies have demonstrated the efficacy of Mucoangin® in relieving pain in acute sore throat, with a fast onset of action and duration of effect of at least 3 hours.

Beside its local anesthetic effect, ambroxol also has anti-inflammatory properties. This anti-inflammatory effect has been shown in vitro to inhibit the release of pro-inflammatory mediators. It has also been proven in patients treated with Mucoangin®, through the reduction of the pharyngeal (throat) redness associated with sore throat.

Mucoangin® can be found in two different pharmaceutical forms: Lozenges and Spray. Both formulations are sold under three different brand names worldwide: Mucoangin, LysopaineAmbroxol, and Lizipadol. All contain ambroxol. Commercialization of Lysopaine and Lizipadol brands is limited to certain countries.

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.

MUCOSOLVAN®

Mucosolvan® - against cough with mucus

Coughing can be a distressful and uncomfortable experience. It is, however, an integral part of the body's self-cleaning mechanism and part of the body's self-protective response. A cough mainly has the function of clearing the airways, thereby protecting the lungs. From a medical perspective, cough is the most common symptom of clinical importance and the most frequent reason to consult a doctor. The clinical symptoms of cough and expectoration (coughing up mucus) have led to the development of drugs that affect respiratory mucus: the so-called mucoactive agents.

Basically, there are two kinds of cough: chesty (productive) and dry (non-productive, persistent, irritating).

A chesty cough, also known as a productive cough, is normally the result of a viral upper respiratory tract infection, such as the common cold. The infection causes the mucous membrane of the airways to become inflamed and to produce thick, sticky mucus, so that it is no longer removed by the body’s normal cleaning action and clogs up the airways. Coughing helps push out this sticky phlegm. Inflammation and too much thick mucus narrow the airways, make breathing difficult, and can promote bacterial infection.

A non-productive cough is dry and tickling - a repeated irritation of the respiratory tract, usually without producing phlegm. Besides respiratory tract infections, this cough can for example also be caused by cigarette smoke, dust or allergies. Sometimes it remains for a couple of days or even weeks as a post symptom of a common cold.

Mucosolvan® is the worldwide leading cough brand with many different formulations developed since the first marketing authorisation in 1978. It contains the mucoactive agent ambroxol.

Mucosolvan® has a 3-way-action: it dissolves phlegm, clears it from the lungs and protects against new phlegm build up

The major product is the syrup with two concentrations of ambroxol, 30 mg/ml and 15mg/5ml. This can be given in adults and children according to local dosing recommendations and registrations.

Other main formulations are sustained release capsules for a one-a-day dosing, and pastilles to be used as on-the-go format. Depending on the country tablets, inhalation, drops, ampoules are also available.

Ambroxol, the active agent of Mucosolvan, has several properties that restore the physiological clearance mechanisms of the respiratory tract and therefore play an important role in the body’s natural defense mechanisms. Ambroxol stimulates synthesis and release of surfactant by specific types of lung cells. Surfactant is a complex emulsion and works as “anti-glue” factor which facilitates an optimal flow of airway secretions.

Several studies have demonstrated the importance of surfactant in reducing the adhesion of mucus to the bronchial wall, in improving its transport, and in providing protection against bacterial aggression and irritating agents.

Mucosolvan® - because breathing drives you!

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.

PHARMATON®

Pharmaton® enhances your physical and mental well-being

Pharmaton® is a multivitamin and mineral supplements brand developed to enhance people's physical and mental well-being. A full range of products adapted to the needs of different target audiences has been developed.

Pharmaton® Vitality, a range of products for adults, contains a unique blend of vitamins, minerals and trace elements and the standardized Ginseng G115 extract. Main target indications are: exhaustion, tiredness, decreasing concentration and mental alertness. Numerous clinical studies showed that a regular intake of Pharmaton® has positive effect on mental and physical performance.

Pharmaton® Kiddi®, a range of products designed for children, contains carefully selected vitamins, minerals and key nutrients that are very important for growth. It is especially recommended in preventive treatment in case of vitamins deficiencies.

Pharmaton® Matruelle® is a pre-natal multivitamins for active planning, pregnant and lactating women, containing all key essential micronutrients for mother and baby like vitamins, minerals and Omega-3 fatty acids. It helps to protect against embryonic neural tube diseases of the fetus and against the iron and folic acids anemia during pregnancy.

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.

THOMAPYRIN®

Thomapyrin® - our pain reliever - contains acetylsalicylic acid, paracetamol, caffeine, and treats mild to moderate headache, migraine attacks, with and without aura, and tension-type headache.

The active ingredients of the triple combination, acetylsalicylic acid, paracetamol and caffeine, suppress pain synergistically via interaction with several pain-related molecular mechanisms. As a result, Thomapyrin® offers faster and superior efficacy compared with its single components, which has been, amongst others, well proven by state-of-the-art clinical studies. For this reason, the triple combination is recommended by many national and international medical societies as first choice for treatment of acute tension-type headache and migraine.

Thomapyrin® is positioned as the expert treatment for headaches.

Two products are available: Thomapyrin® CLASSIC for headache, Thomapyrin® INTENSIV for stronger headache and migraines.

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.

ZANTAC®

Prevent and relieve heartburn with Zantac®

The feeling of heartburn can be described as a burning discomfort that generally occurs in the chest just behind the breastbone. People with heartburn may also experience a sensation of food coming back into the mouth that may be accompanied by a bitter or acid taste.

Heartburn symptoms can occur if your stomach produces too much acid in the digestion process. When this happens, stomach acid can move up into the esophagus, causing discomfort. Heartburn can be caused by diet and lifestyle choices, and different people experience heartburn in different ways.

Zantac® is available in the USA and is a nonprescription acid reducer for the prevention and relief of heartburn associated with acid indigestion and sour stomach brought on by eating or drinking certain foods and beverages. The active ingredient in Zantac®, ranitidine, has been prescribed by doctors for years to treat millions of patients safely and effectively.

Zantac® products work fast to prevent heartburn when taken 30 to 60 minutes before a meal or to provide quick relief for tough heartburn symptoms once they've started. Zantac® begins to work in as little as 30 minutes and provides heartburn relief for up to 12 hours, day or night. It is available in two different dosages in the US, 75 mg and 150mg, and in Cool Mint flavor.

Zantac® has been a trusted name in heartburn relief for more than two decades. It is the #1 doctor recommended H2 brand among over the counter brands.

Read the patient information leaflet carefully. If you have any questions, ask your doctor or pharmacist.

Annual Report Website

Annual Report Microsite