Patients usually notice motor symptoms, like hand tremor (shaking), as their first sign of the disease, which progresses eventually to include shaking of the arms, legs or head. Other motor symptoms that develop over time include stiffness that often results in loss of facial expression and a gradual slowing or loss of motion or "freezing".
About 30-40 % of patients also suffer from non-motor symptoms associated with PD, such as depression and sleep disorders. These are often equally important to them and have an enormous impact on their health-related quality of life, as everyday tasks such as dressing, walking, speaking and even writing, become increasingly difficult. PD is therefore considered to be a much more complex syndrome involving motor, as well as non-motor symptoms, and a balanced treatment approach capable of managing these symptoms is required in order to minimise significant functional disability as much as possible.
The clinical benefits of early initiation of dopaminergic therapy on motor, as well as on non-motor symptoms, have become the focus of intensive medical research.
Poor adherence to long term therapies severely compromises the effectiveness of treatment. The once daily dosing has been shown to improve patient compliance in PD.
Mirapex®, Mirapexin®, Sifrol®, Pexola®
Mirapex® extended release, Mirapexin® extended release, Sifrol® Retard, Pexola® extended release
Indicated in the symptomatic treatment of idiopathic Parkinson's disease. It may be used as monotherapy or in combination with levodopa. Pramipexole is available as once-daily oral prolonged relase tablets and as immediate release tablets to be taken in equally divided doses three times a day.
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